Product ID:NICOTINIC ACID CELL CULTURE TESTED, N0761
MSDS Date:01/01/1999
FSC:6550
NIIN:00N093179
Status Code:A
MSDS Number: CJXHX

Emergency Phone: 314-771-5765

Info Phone: 314-771-5765

Cage: 21076

Telephone: 314-771-5765

Cage: 21076

NICOTINAMIDE; (NICOTINIC ACID)

CAS: 98-92-0

RTECS: QS3675000

OSHA PEL N/K

ACGIH TLV: N/K

LD50 LC50 Mixture:SEE TOXICOLOGICAL INFORMATION.
Routes of Entry: Inhalation:YES Skin:YES Ingestion:YES
Reports of Carcinogenicity:NTP:NO IARC:NO OSHA:NO
Health Hazards Acute and Chronic:ACUTE: MAY BE HARMFUL BY INHALATION,
INGESTION/SKIN ABSORPTION. CAUSES EYE & SKIN IRRITATION. MATERIAL
IS IRRITATING TO MUCOUS MEMBRANES & UPPER RESPIRATORY TRACT. MAY
PRODUCE REVERSIBLE LIVER DAMAGE. TO THE BEST OF MANUFACTURER'S
KNOWLEDGE, THE CHEMICAL, PHYSICAL, & TOXICOLOGICAL PROPERTIES HAVE
NOT BEEN THOROUGHLY INVESTIGATED. OVEREXPOSURE TO NICOTINIC ACID
CAN PRODUCE POWERFUL PERIPHERAL VASOD ILATING ACTION. THIS EFFECT
IS SEEN AS INTENSE FLUSHING OF SKIN & OCCURS ABOUT 15 TO 60 MINUTES
AFTER EXPOSURE. IT IS ACCOMPANIED BY SENSE OF WARMTH, TINGLING, &
ITCHING OF SKIN & SUBSIDES GRADUALLY O VER A PERIOD OF 15 TO 30
MINUTES.
Effects of Overexposure:SEE HEALTH HAZARDS.

First Aid:EYES: IMMEDIATELY FLUSH WITH COPIOUS AMOUNTS OF WATER FOR AT
LEAST 15 MINUTES. SKIN: IMMEDIATELY WASH WITH SOAP AND COPIOUS
AMOUNTS OF WATER. INHALATION: REMOVE TO FRESH AIR. IF NOT
BREATHING, GIVE AR TIFICIAL RESPIRATION. IF BREATHING IS DIFFICULT,
GIVE OXYGEN. INGESTION: WASH OUT MOUTH WITH WATER PROVIDED PERSON
IS CONSCIOUS. CALL A PHYSICIAN. WASH CONTAMINATED CLOTHING BEFORE
REUSE.

Extinguishing Media:WATER SPRAY, CARBON DIOXIDE, DRY CHEMICAL POWDER OR
APPROPRIATE FOAM.
Fire Fighting Procedures:WEAR NIOSH APPROVED SELF-CONTAINED BREATHING
APPARATUS AND FULL PROTECTIVE EQUIPMENT .
Unusual Fire/Explosion Hazard:EMITS TOXIC FUMES UNDER FIRE CONDITIONS.

Spill Release Procedures:WEAR NIOSH APPROVED RESPIRATOR, CHEMICAL
SAFETY GOGGLES, RUBBER BOOTS AND HEAVY RUBBER GLOVES. SWEEP UP,
PLACE IN A BAG AND HOLD FOR WASTE DISPOSAL. AVOID RAISING DUST.
VENTILATE AREA AND WASH SPILL S ITE AFTER MATERIAL PICKUP IS
COMPLETE.

Handling and Storage Precautions:DO NOT BREATHE DUST. AVOID CONTACT
WITH EYES, SKIN AND CLOTHING. KEEP TIGHTLY CLOSED. STORE IN A COOL
DRY PLACE.

Respiratory Protection:NIOSH APPROVED RESPIRATOR.
Ventilation:MECHANICAL EXHAUST REQUIRED.
Protective Gloves:COMPATIBLE CHEMICAL-RESISTANT GLOVES.
Eye Protection:ANSI APPROVED CHEMICAL WORKERS GOGGLES .
Other Protective Equipment:EYEWASH AND DELUGE SHOWER MEETING ANSI
DESIGN CRITERIA .
Work Hygienic Practices:WASH THOROUGHLY AFTER HANDLING.
Supplemental Safety and Health
MF: C*6H*5NO*2. EC NUMBER: 200-441-0.

Melt/Freeze Pt:>236.C, 456.8F
M.P/F.P Text:236C TO 239C
Appearance and Odor:WHITE POWDER.

Stability Indicator/Materials to Avoid:YES
STRONG OXIDIZING AGENTS.
Hazardous Decomposition Products:TOXIC FUMES OF CARBON MONOXIDE, CARBON
DIOXIDE, NITROGEN OXIDES.

Waste Disposal Methods:DISSOLVE OR MIX THE MATERIAL WITH A COMBUSTIBLE
SOLVENT AND BURN IN A CHEMICAL INCINERATOR EQUIPPED WITH AN
AFTERBURNER AND SCRUBBER. OBSERVE ALL FEDERAL, STATE AND LOCAL
ENVIRONMENTAL REGULATIONS.

Toxicological Information:RTECS # QT0525000, NICOTINIC ACID. TOXICITY
DATA: ORL-RAT LD50: 7 GM/KG; NIIRDN 6, 544, 1982. IPR-RAT LD50: 730
MG/KG; OYYAA2 14, 741, 1977. SCU-RAT LD50: 5 GM/KG; NIIRDN 6, 544,
1982. ORL-MUS LD50: 3 720 MG/KG; OYYAA2 7, 149, 1973. IPR-MUS LD50:
358 MG/KG; OYYAA2 14, 741, 1977. SCU-MUS LD50: 3500 MG/KG; OYYAA2
14, 741, 1977. IVN-MUS LD50: 5 GM/KG; THERAP 26, 831, 1971. UNR-MUS
LD50: 4 GM/KG; BAXXD U #2041937. ORL-RBT LD50: 4550 MG/KG; OYYAA2
14, 741, 1977. ONLY SELECTED REGISTRY OF TOXIC EFFECTS OF CHEMICAL
SUBSTANCES (RTECS) DATA IS PRESENTED HERE. SEE ACTUAL ENTRY IN
RTECS FOR COMPLETE INFORM ATION.

Disclaimer (provided with this information by the compiling agencies):
This information is formulated for use by elements of the Department
of Defense. The United States of America in no manner whatsoever,
expressly or implied, warrants this information to be accurate and
disclaims all liability for its use. Any person utilizing this
document should seek competent professional advice to verify and
assume responsibility for the suitability of this information to their
particular situation.

Ecological:DATA NOT YET AVAILABLE.

Transport Information:CONTACT SIGMA CHEMICAL COMPANY FOR TRANSPORTATION
INFORMATION.

Federal Regulatory Information:EUROPEAN INFORMATION: IRRITANT. R
36/37/38: IRRITATING TO EYES, RESPIRATORY SYSTEM AND SKIN. S 26: IN
CASE OF CONTACT WITH EYES, RINSE IMMEDIATELY WITH PLENTY OF WATER
AND SEEK MEDICAL ADVICE. S 36: W EAR SUITABLE PROTECTIVE CLOTHING.
REVIEWS, STANDARDS, AND REGULATIONS: OEL=MAK. OEL-RUSSIA: STEL 1
MG/M3 JAN 1993. NOHS 1974: HZD 81908; NIS 10; TNF 1815; NOS 19; TNE
13494. NOES 1983: HZD 81908; NIS 15; TNF 3028; NOS 46; TNE 61057;
TFE 26152. EPA TSCA SECTION 8 (B) CHEMICAL INVENTORY. EPA TSCA TEST
SUBMISSION (TSCATS) DATA BASE, JUNE 1998.
State Regulatory Information: